![]() ![]() ![]() Regulatory agencies, including the US FDA, Japan Pharmaceutical and Medical Device Agency (PMDA), China Food and Drug Administration (CFDA), and the UK Medicines and Healthcare Products Regulatory Agency (MHRA), all use Phoenix WinNonlin to evaluate drug submissions. It is the industry standard for non-compartmental analysis (NCA), pharmacokinetic/pharmacodynamic (PK/PD), and toxicokinetic (TK) modeling with a proven 30-year history. Phoenix WinNonlin is used by over 10,000 scientists at more than 1,500 establishments in 60 countries. ![]() Phoenix WinNonlin™’s integrated tools for data processing, graphing & charting, report generation, and compliance create an efficient, all-in-one collaboration workbench. PK/PD and non-compartmental analyses can be time consuming, requiring detailed attention to every step from data preparation to report generation. For more information, visit Top 5 reasons why experts choose Phoenix WinNonlin as their preferred software for NCA and PK/PD modeling in studies ranging from preclinical and toxicokinetic (TK) studies to clinical and first in human studies. Phoenix winNonlin with intuitive graphical user interface which allows users to spend less time learning the software and managing data and more time to model, interpret, and understand the data. The integrated tools for data processing, non-compartmental analysis (NCA), PK/PD modeling, toxicokinetic analysis, post-analysis statistics, table creation, and graphics create an all-in-one collaboration workbench for analysts, reviewers, medical writers, and quality assurance team members. for a table or listing, PKconc for your NCA and GraphConc for any graphs, remember that you may want to consider some nominal number other than zero if you want to be able to plot them on a log scale.Phoenix WinNonlin is the industry standard for the analysis of pharmacokinetic and pharmacodynamic data. The created column PKconc is the one you would map to you NCAįor plotting purposes if you want all BLQs to be set to zero then you could feed the output into a second BQL object (or DataWizard since there is no need to identify position within the profile) and create GraphConc with your required substitution. Set all other BQL after Tmax to a missing value e.g. Here is a simpler example that would be suitable for extravascular admin as it helps report Tlag if present (if IV i wouldn't set PreDose values to zero since I want to back extrapolate to a predicted C0) However, if you do want BQLs to be replaced according to rules dependent on their position then you can use the BQL wizard. If your " main problem is setting BLQs to missing for the NCA" then you don't need to do anything since it is already text then it is already numerically missing and you could use the conc column as it is directly in NCA, you don't need to prep it first with the BQL wizard ![]()
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